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The CHAPEROME project investigates how molecular chaperones influence mRNA translation in human cells. By understanding their role in protein synthesis and cellular responses to stress, the project aims to uncover mechanisms that link translation efficiency to cellular needs, with potential implications for diseases re…
CHAPEROME aims to establish a new concept in which molecular chaperones regulate central aspects of mRNA translation in human cells under physiological conditions, in response to proteotoxic stress, and during cellular differentiation.
Recent findings indicate that the folding of translation factors relies on specific chaperone proteins to achieve their functional states.
We hypothesize that chaperones play a pivotal role in aligning translation rates, efficiency, and mRNA selection with the cel…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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