CORDIS Project
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This project investigates how synaptic inputs at the distal dendrites of central neurons are integrated to produce neuronal outputs. By using light-activated ion channels, it aims to explore the generation of dendritic spikes and the functional role of these distal dendritic structures in the neocortex.
The aim of the current proposal is to investigate how synaptic inputs that innervate the distal dendrites of central neurons are integrated to form a neuronal output.
The distal dendritic tree is the dendritic compartment furthest away from the action potential initiation zone.
In the neocortex ascending afferent and intra-cortical information converges in neocortical layer 1 suggesting a prominent functional role, however only the most distal apical dendrites of layer 5 pyramidal neurons enter…
MEDICAL RESEARCH COUNCIL
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