CORDIS Project
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This project investigates the regulation of the type 1 ryanodine receptor (RyR1) through post-translational modifications and small molecules. By utilizing advanced imaging techniques, the project aims to improve the understanding of RyR1's structure and function, which is crucial for calcium signaling in muscle cells.
This proposal is aiming at understanding the structural basis of the type 1 ryanodine receptor (RyR1) regulation by post-translational modifications and by small molecules.
RyR1 is present on the sarcoplasmic and endoplasmic reticuli of many mammalian cell types, most notably, in skeletal muscles.
RyR channels are required for calcium release from intracellular stores, a process essential for excitation-contraction (EC) coupling in skeletal (RyR1) and cardiac (RyR2) muscles.
They are amongst the…
BEN-GURION UNIVERSITY OF THE NEGEV
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