CORDIS Project
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The project aims to develop zebrafish larvae as a model to study cystic fibrosis, focusing on the role of the cystic fibrosis transmembrane conductance regulator in inflammation and infection. This research seeks to identify new therapeutic approaches to improve patient outcomes.
Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
Chronic pulmonary infections accompanied by persistent neutrophil-dominated inflammation result in severe progressive lung injury and are the leading causes of morbidity and mortality of CF patients.
In addition to known mucociliary defects, several lines of evidence suggest primary alterations in innate immune responses contribute to CF pathology.
Currentl…
THE UNIVERSITY OF SHEFFIELD
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