CORDIS Project
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This project studies cell competition mechanisms in stem cells, focusing on how less-fit cells are eliminated during development. It explores the role of the mTOR pathway in regulating this process, aiming to enhance understanding of tissue formation and degeneration prevention.
Understanding the mechanisms that eliminate unfit cells during development is key not only for proper organ formation but also to prevent tissue degeneration in the adult.
Cell competition is a fitness quality control mechanism that occurs between cells of differing fitness levels and results in the selective elimination of those cells that, although viable, are deemed to be less fit than their neighbours.
Cell competition is conserved from Drosophila to mammals and although some important regul…
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