CORDIS Project
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This project aims to determine the high-resolution structure of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a protein crucial for chloride ion transport in epithelial cells. Understanding its structure will aid in developing targeted treatments for cystic fibrosis.
This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells.
Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins whic…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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