CORDIS Project
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This project explores how different forms of AMPA-type glutamate receptors affect brain function, particularly in learning and memory. By studying specific neuron types, it aims to clarify the role of receptor diversity in synaptic activity and its implications for therapeutic development.
AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission in the central nervous system and are key regulators of synaptic plasticity, learning, and memory. AMPARs are tetrameric receptors assembled from GluA1–4 subunits, whose molecular diversity is shaped by alternative splicing, RNA editing, and association with auxiliary proteins.
The flip/flop isoforms of generated through alternative splicing and the mRNA editing significantly affect receptor kinetics, trafficking, a…
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