CORDIS Project
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This project explores the role of centrosome amplification in breast cancer and its effects on the tumor microenvironment. It aims to characterize how extra centrosomes influence tumor growth and immune response, potentially revealing new pathways for cancer development.
The centrosome, an organelle important for cell division, is frequently amplified in cancer, including breast cancer.
In this fellowship I propose to investigate how cells with centrosome amplification change the tumour microenvironment (TME) to promote breast cancer development.
Recent work has shown that having extra centrosomes drive tumour growth in vivo, indicating that centrosome amplification is not a bystander of cancer, but promotes tumorigenesis.
Consistent with a direct role in cancer…
QUEEN MARY UNIVERSITY OF LONDON
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