CORDIS Project
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The CENTROSHAPE project investigates the structure and function of centromeres in vertebrate chromosomes, focusing on their bipartite nature. It aims to uncover how these structures contribute to chromosome stability during cell division and their implications in cancer.
The centre of the iconic X-shape of human chromosomes is the centromere.
It is an extensive locus of specialised chromatin that assembles the kinetochore machinery to connect chromosomes to spindle microtubules for their correct segregation during cell division.
How these centromeres obtain three-dimensional (3D) structures that coordinate assembly of kinetochores and resist substantial microtubule-based pulling forces is unknown.
We discovered that vertebrate chromosomes are naturally dicentric…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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