CORDIS Project
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This research focuses on the biogenesis of centrosomes using fruit flies as a model organism. By studying the molecular interactions and dynamics of key proteins involved in centriole assembly, the project aims to uncover insights into the regulation of centrosome numbers, which is crucial for understanding cancer biol…
Centrosomes are organelles composed of a pair of centrioles surrounded by a pericentriolar matrix (PCM) that perform a variety of key functions in the animal cell.
Centrosomes duplicate precisely once during S-phase of the cell cycle; in G2-phase the two centrosomes move to opposite locations around the nucleus and expand their PCM to nucleate vast quantities of microtubules for mitotic spindle formation.
Dysfunctions in the centrosome cycle have been associated with a wide range of pathologies…
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