CORDIS Project
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This project investigates the molecular mechanisms regulating centriole length and the formation of cilia and flagella. It focuses on the interactions between key proteins involved in these processes, utilizing advanced techniques in bioinformatics, biochemistry, and cell biology to enhance our understanding of centrio…
Centrioles play a key role in the assembly of the centrosome, the major microtubule organizing center, and are crucial for the formation of cilia and flagella.
Significant progress has been made toward understanding centriole biogenesis, but the mechanisms that determine centriole length and prevent centrioles from forming cilia or flagella remain unknown. CP110, Cep97, Cep120, CPAP, SPICE1 and centrobin have been identified as key players in these fundamental biological processes.The overarchin…
PAUL SCHERRER INSTITUT
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