CORDIS Project
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This project aims to enhance personalized immunotherapy for brain tumors by utilizing tumor-reactive T cell receptors. By employing machine learning to predict effective T cell responses, the research seeks to develop targeted therapies that improve treatment outcomes for patients.
Personalized tumor immunotherapy - vaccines and T cell therapies - requires the selection of few immunogenic epitopes recognized by tumor-reactive T cell receptors (TCRs) from thousands of potential tumor antigens in each tumor.
This selection is a huge challenge, particularly in brain tumors, where access to tumor tissue is limited and tumor-infiltrating T cells (TILs) are sparse. CENTRIC-BRAIN will reverse this epitope-centric approach by directly harnessing tumor-reactive orphan TCRs from TIL…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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Germany, Heidelberg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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