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CENStruK investigates the assembly of the inner kinetochore complex in yeast, crucial for accurate chromosome segregation. By reconstituting key protein interactions and studying a unique yeast strain, the project aims to enhance understanding of genetic material segregation in eukaryotes.
Ensuring accurate segregation of the genetic material is an essential life process.
In eukaryotes, such as humans and yeasts, regions of DNA known as centromeres nucleate the assembly of the megadalton kinetochore complex, which connects to and regulates spindle-microtubules that drive chromosome segregation.
While significant progress has been made in the past decade in understanding the structural architecture of the inner kinetochore Ctf19 complex (CCAN in humans), a fundamental gap in knowle…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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