CORDIS Project
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This project explores the role of RNA in centromere function and chromosome segregation. It aims to understand how non-coding RNAs regulate centromeres and their heritable features, using Drosophila and human cells to identify associated proteins and mechanisms.
One of the most astonishing processes in the life of a cell is the division into two daughter cells.
Such a highly organized process would presumably be regulated tightly by the underlying centromeric DNA sequence; however, the sites of chromosome attachment to the microtubule spindle are regulated by epigenetic mechanisms.
The best-characterized epigenetic mark for centromeres is the histone H3-variant CENP-A, which replaces H3 in some of the nucleosomes within centromeric chromatin.
Centromere…
KARLSRUHER INSTITUT FUER TECHNOLOGIE
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Germany, Heidelberg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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