CORDIS Project
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This project investigates the role of protein phosphatases in Aspergillus fumigatus, a significant fungal pathogen. It aims to understand how these proteins contribute to the fungus's ability to withstand treatments and its virulence in infected hosts.
Aspergillus fumigatus is the most important air-borne fungal pathogen, causing severe infections with invasive growth in immunocompromised patients.
For growth in all habitats, the fungus needs to be able to sense environmental stimuli and to transduce signals via specific signalling cascades.
Calmodulin/calcineurin, Ras/cAMP, mTOR and general Mitogen-activated protein kinase (MAPK) signalling pathways are involved in the regulation of various cellular responses in eukaryotes.
Previous studies r…
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-INSTITUT
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