CORDIS Project
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This project explores how cells interact with their extracellular matrix through mechanical probing. It aims to develop a theoretical framework to understand cell behavior and network remodeling, with implications for biological implants and disease prevention.
Inside tissues, living cells can adhere to a heterogeneous fiber network, the extracellular matrix (ECM).
Cells adjust their behavior in response to the local resistance they sense from pulling the neighboring fibers (mechanosensing).
As they probe the network and respond to signals, cells can strongly distort the ECM and these deformations can serve as cues for other cells.
The cell-generated forces can be large enough to trigger non-linear elastic effects and irreversible transformations of th…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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