CORDIS Project
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This project aims to understand how physical forces influence cell behavior and fate decisions. By studying the mechanical structures in cells, particularly in fibroblasts and heart muscle cells, the research seeks to connect physical stimuli with biochemical responses.
Biological cells possess a chemical “sense of smell” and a physical “sense of touch”.
Structure, dynamics, development, differentiation and even apoptosis of cells are guided by physical stimuli feeding into a regulatory network integrating biochemical and mechanical signals.
Cells are equipped with both, force-generating structures, and stress sensors including force-sensitive structural proteins or mechanosensitive ion channels.
Pathways from force sensing to structural and transcriptional con…
GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
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