CORDIS Project
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This project focuses on reprogramming glial cells into specific neuronal subtypes to address neuronal loss due to brain injuries and neurodegenerative diseases. By utilizing innovative molecular techniques, it aims to enhance the conversion process and improve brain repair strategies, particularly targeting the thalamo…
Neuronal loss is at the core of cognitive and functional failures of both acute brain injuries and neurodegenerative diseases.
Direct neuronal reprogramming of local glial cells is emerging as a promising approach for restorative brain therapy.
However, in order to use direct glia-to-neuron reprogramming for the treatment of neuronal loss we still need to address a number of challenges, namely reliable and long-term conversion into the desired neuron subtype.
In this proposal we aim to generate…
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