CORDIS Project
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This project investigates the molecular mechanisms of cell fusion using the yeast model Schizosaccharomyces pombe. It aims to understand the roles of cell signaling, polarization, and the actin-based fusion machinery, which are essential for processes like fertilization, regeneration, and cancer development.
Cell fusion is critical for fertilization and development, for instance underlying muscle or bone formation.
Cell fusion may also play important roles in regeneration and cancer. A conceptual understanding is emerging that cell fusion requires cell-cell communication, polarization of the cells towards each other, and assembly of a fusion machinery, in which an actin-based structure promotes membrane juxtaposition and fusogenic factors drive membrane fusion.
However, in no single system have the…
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