CORDIS Project
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The project focuses on understanding the mechanisms of cell growth and division by reconstituting the cell cycle oscillator in vitro. It combines advanced biochemistry and synthetic biology to develop sensors and models that will help identify the core components and their interactions, ultimately providing insights in…
Cell growth and division are the basis of all forms of life.
In eukaryotes, the clock-like cycles of genome duplication and cell division are orchestrated by a complex set of biochemical reactions.
Theory suggests that a negative feedback loop regulating the cyclin-dependent kinase 1 generates the cell cycle oscillations; however, because the putative cell cycle ‘clock’ is tightly interlinked with numerous other biological networks, experimental validation has proven to be a challenge.
To date,…
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