CORDIS Project
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This project explores the role of the SUMO conjugation pathway in the roundworm Caenorhabditis elegans, focusing on its impact on DNA damage response and meiotic recombination. It utilizes advanced mass spectrometry techniques to analyze the SMO-1 proteome.
SUMO (small ubiquitin-like modifier) is a small peptide that can be covalently attached to target proteins in an analogous way to ubiquitin. SUMO is involved in transcriptional regulation, sub-cellular partitioning, stress response, and DNA damage response, among other processes.
The roles for the SUMO conjugation pathway have been mainly addressed using transformed cell lines and yeast.
To address the relevance of the SUMO conjugation pathway in a living organism, I will use the round worm, Cae…
UNIVERSITY OF DUNDEE
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