CORDIS Project
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This project investigates how the gut's nerve cells and supporting cells interact with gut microbiota to influence the production of neuroregulatory molecules. By studying specific genetic mutations in mice and their response to different microbiota, the project aims to uncover new pathways that could lead to therapies…
The enteric nervous system (ENS), neuronal and glial cells, development and function can be influenced by the microbiota.
Germ-free mice have defective maturation of enteric glial and neuronal cells; colonization with microbiota rescues these defects.
Production of neuroregulatory molecules by these neuronal cells involved microbial product sensing via MYD88.
Importantly, glial-specific or neuron-specific deletion of Myd88 leads to decreased intestinal neuroregulators and consequent impaired inn…
FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
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