CORDIS Project
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This project investigates the genetic and phenotypic characteristics of Clostridium difficile, particularly focusing on the hypervirulent 027 strains. By creating and analyzing mutants, the research aims to enhance understanding of how these strains develop increased virulence, contributing to better management of infe…
Clostridium difficile is a Gram-positive, spore-forming anaerobic bacillus that often resides in the gut of mammals and is the causative agent of the illness C. difficile infection (CDI).
The hospital environment and patients undergoing antibiotic treatment provide a discrete ecosystem where C. difficile persists and select virulent clones thrive. CDI is the most frequent cause of infectious diarrhea in hospitals worldwide, causing in the last decade outbreaks of increased severity in Europe and…
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
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