CORDIS Project
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This project aims to understand the mechanisms regulating CD4 T-cell responses in immune reactions, particularly in cancer and autoimmune diseases. By identifying negative regulators of T-cell migration and activation, the research seeks to enhance the effectiveness of cancer immunotherapy.
The fine and complex regulation of CD4 immune response is important in cancer, autoimmune diseases, inflammatory disorders and viral infection.
If signals orchestrating productive CD4 T-cell responses are well documented, the contraction of antigen (Ag)-specific CD4 T-cell populations following the resolution of primary immune response is however not molecularly understood.
It has been demonstrated that a negative feedback loop can regulate CD4 T cell proliferation through direct T-T interaction…
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