CORDIS Project
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This project investigates the role of sialic acid in regulating the CD28 receptor's co-stimulatory activity on T cells, which is crucial for immune responses against cancer and chronic infections. It aims to uncover the structural mechanisms behind this regulation and develop new strategies to reactivate exhausted T ce…
Regulation of T cells has been a cornerstone in the development of therapeutics for fighting a wide plethora of pathologies, including cancer, chronic infections and disease.
The mechanisms governing activation or repression of T cells depend on several receptors which provide “second signals” following the initial interaction with APCs presenting MHC complexes.
Among these receptors, CD28 constitutes the main interest for this project.
Its role as co-stimulator of T cell activity is known for s…
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United States, LA JOLLA
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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