CORDIS Project
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This project focuses on understanding the immune system's response in Crohn's Disease patients, particularly why some do not respond to TNF-blocking therapies. By analyzing immune cell behavior at a single-cell level, it aims to identify biomarkers for better patient stratification and treatment strategies.
Crohn´s Disease (CD) is a chronic inflammatory disease that affects the gastrointestinal tract, affecting millions of people worldwide and presenting a considerable economic burden to health systems. CD has a serious impact in quality of life, not just physically, but also emotionally and socially.
Pathogenesis results from a complex interaction between environmental factors, microbiome, genome, and inflammatory system, leading to disruption of the intestinal mucosa.
The imbalance between inflam…
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