CORDIS Project
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This project investigates how different types of cadherins, proteins that mediate cell adhesion, influence tissue development and cancer invasion. By examining their roles in normal branching morphogenesis and cancer cell behavior, the research aims to uncover mechanisms that could inform therapeutic strategies for epi…
Cadherin-based cell-cell junctions regulate tissue architecture by coordinating multicellular growth and polarity.
In addition to the ubiquitously expressed and widely studied E-cadherin, epithelia express other, more tissue-specific classical cadherins, often particularly during developmental epithelial rearrangements.
These additional cadherins recently also have been implicated in tumor progression, but their expression and function is poorly understood.I recently demonstrated that differen…
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