CORDIS Project
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This project aims to develop a targeted treatment for T-cell Acute Lymphoblastic Leukemia by inhibiting the NOTCH signaling pathway. The small molecule compound CB-103 shows promise in significantly prolonging survival rates without the adverse effects associated with traditional chemotherapy, potentially benefiting ot…
T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive NOTCH-dependent cancer that affects the blood and bone marrow especially in children aged 0-14 years, and currently has no effective cure. T-ALL accounts for about 25% of the total cases of Lymphoblastic Leukemia (ALL); additionally, an estimated 250,000 people are afflicted by NOTCH-dependent cancers every year.
Chemotherapy, the standard-of-care treatment for T-ALL, can reduce tumor growth, but it is ineffective at killing the cancer…
CELLESTIA BIOTECH AG
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