CORDIS Project
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This project investigates heart regeneration differences between two populations of the fish Astyanax mexicanus. By analyzing scarring and immune responses, it aims to identify molecular mechanisms that could inform therapies for healing human hearts after myocardial infarction.
Whereas the human heart cannot regenerate cardiac muscle after myocardial infarction, certain fish efficiently repair their hearts.
Astyanax mexicanus, a close relative of the zebrafish, is a single fish species comprising cave-dwelling and surface river populations.
Remarkably, while surface fish regenerate their heart after injury, cavefish cannot and form a permanent fibrotic scar, similar to the human heart.
Using transcriptomics analysis and immunohistochemistry, we have identified key diff…
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