CORDIS Project
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This project focuses on synthesizing Calyciphylline K and related compounds using a novel method. It aims to evaluate their anticancer properties through cell viability assays and further pharmacological studies.
Calyciphylline K is a Daphnezomine L-type natural product with promising anticancer activity.
We propose to complete the total synthesis of Calyciphylline K and several closely-related Daphnezomine L alkaloids by developing a novel asymmetric organocatalytic Malononitrile Michael Addition methodology to facilitate their preparation in a short sequence of around 12 synthetic steps.
The anticancer activity of Calyciphylline K and other analogues prepared during this study will then be evaluated us…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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