CORDIS Project
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This project develops a new synthetic method for producing strychnos alkaloids, which have significant therapeutic potential. The approach aims to efficiently create complex molecular structures to facilitate further biological studies.
A new catalytic enantioselective cycloisomerisation reaction for the direct creation of the azabicyclic core of strychnos alkaloids is proposed.
Strychnos alkaloids have been the subject of intensive investigation over the last decades.
Recently, leuconicines A and B, which are new members of the Strychnos alkaloid family, have been isolated from extracts of the Malaysian plant Leuconotis maingayi.
Leuconicines possess significant bioactivity and they potently reverse multidrug resistance in vi…
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