CORDIS Project
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This project focuses on developing new catalytic methods for the asymmetric synthesis of chiral compounds, which are crucial for many pharmaceuticals. By creating innovative processes using organometallic intermediates, it aims to enhance the efficiency and diversity of drug discovery.
Medicinal chemistry requires more efficient and diverse methods for the asymmetric synthesis of chiral scaffolds.
Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers.
There is a compelling correlation between drug candidate “chiral complexity” and the likelihood of progression to the marketplace.
Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the “chira…
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