CORDIS Project
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This project focuses on developing new methods for creating carbon-carbon bonds using organolithium reagents in asymmetric synthesis. It aims to enhance the efficiency and selectivity of these reactions, which are crucial for producing complex organic molecules.
Carbon–carbon bond formation is at the hearth of chemistry and the development of new methodology for catalytic enantioselective C-C bond formation continues to be a major challenge for synthesis.
After more than 80 years since the introduction of organolithium reagents, no general, highly enantioselective and practical catalytic C-C bond formation with organolithium reagents exists.
In preliminary studies, Feringa´s group have recently discovered that simple alkyl lithium reagents (MeLi, n-BuLi…
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