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The CASTedit project aims to enhance gene editing technologies by utilizing CRISPR-associated transposon systems. This approach allows for the insertion of large DNA segments into specific genomic locations without damaging the DNA, making it particularly useful for applications in mammalian cells and regenerative medi…
The rapid advancements in CRISPR-Cas technology have revolutionized gene editing, yet significant challenges persist, particularly the reliance on DNA Damage Response (DDR) pathways and the limitations in integrating large DNA segments.
These constraints hinder the application of CRISPR-Cas systems, especially in non-dividing cells and complex genomic modifications.
The recently discovered CRISPR-associated transposon (CAST) systems offer a transformative solution, enabling the insertion of larg…
KOBENHAVNS UNIVERSITET
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