CORDIS Project
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This project focuses on developing new enantioselective methods using small organic catalysts to achieve high levels of selectivity and reactivity in organic synthesis. It aims to integrate multiple chemical transformations into a single process, particularly for the synthesis of anti-cancer compounds, while reducing c…
Enantioselective catalysis is the most important frontier of synthetic organic chemistry today.
As nature uses enzymes to catalyze highly stereoselective reactions, it was long assumed that large and complex structures are essential to attain high enantioselectivity.
However, it has now been illustrated by MacMillan and others that small molecule organic catalysts can compete with the enantioselectivity and reactivity levels of enzymes, omitting the need for highly toxic organometallic catalysts…
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