CORDIS Project
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This project aims to develop a targeted therapy for Parkinson’s disease by creating alpha-Synuclein-specific regulatory T cells that suppress neuroinflammation. By using patient-derived cells, the project seeks to provide a localized treatment approach with minimal side effects, potentially benefiting patients at any d…
Mounting evidence has defined the key role played by the immune system in exacerbating dopaminergic neuron loss in Parkinson’s disease (PD).
Pathological alpha-Synuclein (αSYN) activates microglia and recruits inflamed T cells, creating a toxic environment that directly negatively impact on neurodegenerative processes.
Blocking or attenuating neuroinflammation can have a strong therapeutic potential in PD, but systemic treatments are associated with immune system general suppression leading to s…
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