CORDIS Project
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This project explores the role of cardiac fibroblasts in heart function by developing murine models to study their interactions with heart muscle cells. The research aims to uncover how these cells influence heart rhythm and could lead to new treatments for heart diseases.
Cardiac connective tissue is regarded as passive in terms of cardiac electro-mechanics.
However, recent evidence confirms that fibroblasts interact directly with cardiac muscle cells in a way that is likely to affect their beat-by-beat activity.To overcome limitations of traditional approaches to exploring these interactions in native tissue, we will build and explore murine models that express functional reporters (membrane potential, Vm; calcium concentration, [Ca2+]i) in fibroblasts, to ident…
UNIVERSITAETSKLINIKUM FREIBURG
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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