CORDIS Project
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This project investigates the role of epigenetics and microRNAs in heart failure, focusing on how these mechanisms regulate gene expression in cardiac cells. By mapping DNA and histone modifications and studying knockout mouse models, the project aims to uncover the underlying causes of heart failure and explore potent…
Heart failure (HF) is the ultimate outcome of many cardiovascular diseases.
Re-expression of fetal genes in the adult heart contributes to development of HF.
Two mechanisms involved in the control of gene expression are epigenetics and microRNAs (miRs).
We propose a project on epigenetic and miR-mediated mechanisms leading to HF.Epigenetics refers to heritable modification of DNA and histones that does not modify the genetic code.
Depending on the type of modification and on the site affected,…
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