CORDIS Project
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This research focuses on how heart disease alters calcium release in heart cells, potentially leading to arrhythmias. By studying the structural changes in calcium channels, the project aims to uncover the mechanisms behind these electrical irregularities in heart function.
Contraction of the heart occurs by the intracellular release of calcium through channels called ryanodine receptors (RyR), after electrical activation.
Due to the progression of heart disease, structural and functional remodeling of at the level of the cardiac cell is known to occur.
This remodeling process alters the electrical properties of the heart muscle cell and can lead to the production of an irregularity in the electrical activity of the heart called an arrhythmia.
Studies have shown a…
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