CORDIS Project
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This project aims to create patient-specific induced pluripotent stem cells to develop in vitro models for studying inherited cardiac disorders. By examining various genetic mutations, the project seeks to enhance understanding of disease mechanisms and enable personalized therapeutic strategies.
The study of several genetic disorders is hampered by the lack of suitable in vitro human models.
We hypothesize that the generation of patient-specific induced pluripotent stem cells (iPSCs) will allow the development of disease-specific in vitro models; yielding new pathophysiologic insights into several genetic disorders and offering a unique platform to test novel therapeutic strategies.
In the current proposal we plan utilize this novel approach to establish human iPSC (hiPSC) lines for the…
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