CORDIS Project
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The CARDINAL project aims to create a 3D model of cardiac muscle using human stem cells to improve drug screening for cardiovascular diseases. By replicating the heart's natural structure, it seeks to enhance the predictivity of drug responses compared to traditional 2D models.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide.
Chronic treatments of CVDs are scarce because of poor predictivity of current two-dimensional (2D) pre-clinical models.
State-of-the-art 3D-tissue models based on human induced pluripotent stem cells (hiPSCs) can be more predictive of human genetics but fail to replicate the 3D cardiac muscle structure.
In fact, the heart evolved to ensure efficient emptying of the chambers via a 3D chiral organization of muscle tissue not…
UNIVERSITA DEGLI STUDI DI PAVIA
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