CORDIS Project
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This project uses the model plant Arabidopsis to study DNA methylation, a key epigenetic mechanism, and its role in stress adaptation. By comparing plant and mammalian methylation processes, the research aims to enhance understanding of epigenetics in agriculture and medicine.
BACKGROUND:
Epigenetic modifications dictate major biological processes, such as control of gene activity during development and genome stability under stress. DNA methylation is a primary epigenetic mechanism mediated by a family of methyltransferase enzymes.
Maintenance function of DNA methylation is well conserved among plants and animals, based on the structural similarity of their methylation proteins.
In contrast to plants, however, mammals do not tolerate loss of methylation, making it di…
UNIVERSITY OF LEEDS
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