CORDIS Project
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This project investigates the role of adult stem cells in the initiation and growth of skin cancer. By using novel methods to isolate specific stem cells in mouse epidermis, the research aims to determine if these cells are the initial targets of mutations that lead to cancer development.
Cancer is the result of a multi-step process requiring the accumulation of mutations in several genes.
For most cancers, the target cells of oncogenic mutations are unknown.
Adult stem cells (SCs) might be the initial target cells as they self-renew for extended periods of time, providing increased opportunity to accumulate the mutations required for cancer formation.
Certain cancers contain cells characteristics of SC with high self-renewal capacities and the ability to reform the parental tumo…
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