CORDIS Project
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This project investigates the role of autophagy in cancer progression using Drosophila models. It aims to understand how manipulating autophagy can influence tumor growth and resistance to treatments, potentially leading to new cancer therapies.
Cancer is one of the most prevalent human killer diseases.
Autophagy, a lysosome-mediated process that degrades cellular components and damaged organelles, has recently emerged as an important player in cancer.
Indeed, autophagy inhibition promotes cancer initiation through generation of genomic instability and inflammation, whereas in contrast, autophagy activation is often required to sustain growth of advanced solid tumours in a nutrient-deprived hypoxic environment.
Recent findings firmly de…
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