CORDIS Project
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This project investigates large intergenic non-coding RNAs (lincRNAs) and their roles in regulating gene expression, particularly in cancer pathways like p53. By combining various biological techniques and analyzing patient samples, the goal is to uncover their mechanisms and potential applications in diagnostics and t…
Mammalian cells express thousands of RNA molecules structurally similar to protein coding genes –they are large, spliced, poly-adenylated, transcribed by RNA Pol II, with conserved promoters and exonic structures –however lack coding capacity.
Although thousands exist, only few of these large intergenic non-coding RNAs (lincRNAs) have been characterized.
The few that have, show powerful biological roles as regulators of gene expression by diverse epigenetic and non-epigenetic mechanisms.
Signifi…
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
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