CORDIS Project
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This project aims to enhance cancer therapy by developing a novel 3D clone-based full-length RNA sequencing technology. It focuses on early detection of rare mutations and transcriptional variations in tumors, which can significantly improve personalized treatment strategies for cancer patients.
Intra-tumor genetic heterogeneity imposes a great challenge on cancer therapy.
Resistance to molecularly targeted therapies and chemotherapy can arise from selective growth of pre-existing sub-clones that carries drug-resistance mutations, altered metabolic and/or epigenomic states, providing a survival advantages.
Early detection of these subclonal states can thus significantly aid cancer therapy.
However, attempts to profile various types of primary cancer cells using single-cell techniques ar…
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