CORDIS Project
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This project explores the role of DNA methylation in cancer and development. It seeks to understand how epigenetic changes in cancer resemble those in the placenta, aiming to uncover the mechanisms behind these alterations and their implications for disease.
DNA methylation is a tightly controlled mechanism that is essential for normal development and genome regulation.
Although maintained in a highly static pattern across healthy tissues, DNA methylation is globally reprogrammed in nearly all malignant cancers, including gains at thousands of gene promoters and global loss across large domains.
Substantial work from our group to characterize multiple primary tumor cohorts, transgenic animal models, and cancer cell lines finds that current experimen…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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