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CancerCirculome investigates how cancer cells generate and incorporate circular DNA, particularly in neuroblastoma, a common childhood cancer. The project aims to understand the mechanisms behind this process to improve cancer diagnosis and treatment.
Recent reports describe the highly unexpected observation that cancer cells have the intrinsic ability to create and chromosomally re-incorporate extrachromosomal circular DNAs.
We could show that these genomic phenomena are more frequent than expected in primary human neuroblastomas, a common childhood tumor, suggesting that DNA circularization represents a major driver of neuroblastoma genome remodeling.
We aim with CancerCirculome to uncover new principles of pediatric cancer genome remodelin…
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