CORDIS Project
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This project develops a novel method, MAPP, to analyze proteasome activity in cancer, focusing on how protein degradation affects tumor growth and immune response. By examining proteasome composition and degradation pathways, it aims to enhance understanding of tumor-immune interactions and improve immunotherapy outcom…
Proteasome activity is crucial to removal of defective or obsolete proteins, cell signaling and antigen presentation.
In cancer, proteasomal degradation was shown to play key roles in tumor growth, antigenicity and response to immunotherapy.
Yet, comprehensive analysis of proteasome subunit composition and the degradation landscape in cancer has not been performed to date, rendering our understanding of inter-patient proteasome heterogeneity and proteasome-dependent mechanisms underlying tumor-i…
WEIZMANN INSTITUTE OF SCIENCE
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