CORDIS Project
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This research investigates how delta9-tetrahydrocannabinol (THC) affects memory formation by analyzing mRNA translation in specific hippocampal neurons. The project aims to understand the molecular mechanisms behind THC-induced memory impairment, potentially informing therapeutic strategies.
The hippocampal region is critically involved in memory formation and cannabinoids including delta9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, are known to impair hippocampus-dependent memories.
Previous findings uncover the role of the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis underlying the long-term amnesic-like effects of THC.
Thus, the regulation of mTOR-dependent mRNA translation after THC exposure could be an important proce…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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